Understanding how a specific gene helps prevent blood clots
Official title: Investigating the functional roles of Arl6ip5 in suppressing thrombosis
Funded at Oakland University · NIH-10796203 · Data updated 2026-11-12
This study is looking at how a specific gene called Arl6ip5 helps stop harmful blood clots, and it's being done with specially modified mice to see what happens when this gene is missing, which could help us learn more about preventing blood clot issues in people.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oakland University NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $450,000 |
| NIH project number | 1R15HL172202-01 |
| Project ID | NIH-10796203 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of thrombosis or those who have experienced thrombotic events.
✕Less likely to help
Patients who do not have a history of thrombotic disorders or related genetic conditions may not benefit from this research.
What this research studies
This research investigates the role of the Arl6ip5 gene in preventing dangerous blood clots, known as thrombosis. By studying genetically modified mice, the researchers aim to understand how the absence of this gene affects blood clotting and platelet function. The project will involve various laboratory assays to assess how changes in this gene influence the body's ability to manage blood clotting and the overall risk of thrombosis. The findings could lead to new insights into genetic factors that protect against clot-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new genetic insights that help prevent thrombosis in patients.
How similar studies have gone: Previous research has shown success in identifying genetic variants that influence thrombosis, making this approach promising.
Where this research is happening
-
Oakland University
Rochester, United States Active
Researchers
- Principal investigator: Westrick, Randal J — Oakland University
- Study coordinator: Westrick, Randal J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.