Understanding how a specific gene fusion contributes to leukemia
The Role of the CBFB-MYH11 Complex in Leukemia Maintenance
This study is looking at a specific gene fusion that may play a big role in how acute myeloid leukemia (AML) develops, with the hope of finding new treatment options that could help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10817797 on NIH RePORTER |
What this research studies
This research investigates the role of the CBFB-MYH11 gene fusion in the maintenance of acute myeloid leukemia (AML). By studying how this fusion protein interacts with other factors in the cell, the researchers aim to identify potential new drug targets that could improve treatment options for patients with AML. The study utilizes mouse models to explore the mechanisms by which this gene fusion influences leukemia development and progression. Patients may benefit from insights gained into the biology of their disease and the development of targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia, particularly those with the CBFB-MYH11 fusion gene.
Not a fit: Patients with other types of leukemia or those without the CBFB-MYH11 fusion may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with acute myeloid leukemia.
How similar studies have performed: Previous research has shown promising results in targeting gene fusions in leukemia, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Hyde, Ricia Katherine — University of Nebraska Medical Center
- Study coordinator: Hyde, Ricia Katherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.