Understanding how a specific gene controls blood vessel growth in the retina
Control of retinal angiogenesis by Tbx3
This study is looking at how a gene called TBX3 helps build and keep the tiny blood vessels in the eye that are important for good vision, and it could help us learn more about eye diseases that can lead to blindness.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-10681385 on NIH RePORTER |
What this research studies
This research investigates the role of the TBX3 gene in the development and maintenance of blood vessels in the retina, which is crucial for vision. By studying mouse models, the researchers aim to uncover how TBX3 influences the formation of retinal ganglion cells and endothelial cells, which are essential for healthy retinal vasculature. The study will involve identifying the specific retinal cells that depend on TBX3 and exploring the gene's transcriptional targets to better understand its function. This knowledge could lead to new insights into retinal diseases that cause blindness.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with retinal diseases or conditions that affect blood vessel growth in the eye.
Not a fit: Patients with retinal conditions unrelated to vascular growth or those who do not have any retinal diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for retinal diseases that result in vision loss.
How similar studies have performed: Previous research has shown that understanding the genetic factors involved in retinal development can lead to significant advancements in treating retinal diseases.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Viczian, Andrea S — Upstate Medical University
- Study coordinator: Viczian, Andrea S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.