Understanding how a specific gene affects tooth regeneration in mice
Official title: A novel GTPase regulator governing the regenerative capacity of murine teeth
Funded at Texas A&m University Health Science Ctr · NIH-11049230 · Data updated 2026-11-12
This study is looking at how a specific gene called Din affects the behavior of stem cells in mouse teeth, which could help us learn more about how to regenerate teeth and improve dental treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | September 12, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $346,938 |
| NIH project number | 1R01DE033676-01A1 |
| Project ID | NIH-11049230 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with dental issues or conditions that affect tooth regeneration and healing.
✕Less likely to help
Patients with fully developed teeth and no regenerative capacity issues may not benefit from this research.
What this research studies
This research investigates the role of a gene called Din in regulating the behavior of stem cells in mouse teeth, which can provide insights into tooth regeneration. By using a special mouse model where this gene is knocked out, researchers can observe how the absence of Din affects the growth and healing of teeth. The study focuses on the mechanisms of stem cell maintenance, migration, and differentiation, which are crucial for effective tooth repair and regeneration. The findings could lead to advancements in regenerative dentistry by enhancing our understanding of stem cell dynamics in dental tissues.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve tooth regeneration and healing in humans.
How similar studies have gone: Other research has shown promising results in understanding stem cell regulation in various tissues, suggesting potential success in this novel approach.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Wang, Xiaofang — Texas A&m University Health Science Ctr
- Study coordinator: Wang, Xiaofang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.