Understanding how a specific gene affects the narrowing of artificial blood vessels used in heart surgery
Elucidating the Molecular Mechanisms Underlying LYST-mediated Tissue Engineered Vascular Graft Stenosis
This study is looking at how a specific gene called LYST affects the narrowing of artificial blood vessels used in heart surgery for kids, with the hope of finding ways to prevent this problem and make these grafts safer and more effective for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-11040441 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the narrowing (stenosis) of tissue-engineered vascular grafts (TEVGs) used in congenital heart surgery. It focuses on a gene called LYST, which has been found to influence the incidence of stenosis in animal models. By studying how mutations in this gene affect the immune response and the role of specific immune cells, the research aims to develop strategies to prevent this complication. The ultimate goal is to improve the safety and effectiveness of artificial blood vessels for patients undergoing heart surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are children with congenital heart defects who may require tissue-engineered vascular grafts during surgery.
Not a fit: Patients who do not have congenital heart defects or do not require vascular grafts may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better outcomes for patients needing artificial blood vessels in heart surgery by reducing complications related to graft narrowing.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic factors in graft complications, indicating that this approach has potential for success.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Breuer, Christopher Kane — Research Inst Nationwide Children's Hosp
- Study coordinator: Breuer, Christopher Kane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.