Understanding how a specific gene affects memory in aging and Alzheimer's disease
NPTX2: Preserving memory circuits in normative aging and Alzheimer's Disease
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-11084458
This study is looking at how a specific gene called NPTX2 affects memory as we get older and how it relates to Alzheimer's disease, to help understand why some people stay sharp while others may struggle with memory loss.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-11084458 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the NPTX2 gene in memory function as people age and in the context of Alzheimer's disease. By examining molecular pathways that influence memory consolidation, the study aims to identify why some individuals maintain cognitive clarity while others develop neurodegenerative diseases. The researchers will utilize advanced techniques such as targeted proteomics and RNA sequencing to analyze brain samples from individuals with varying cognitive abilities. This approach will help uncover the mechanisms behind cognitive resilience and decline in aging.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are experiencing cognitive changes or have a family history of Alzheimer's disease.
Not a fit: Patients who are currently diagnosed with advanced Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving memory and cognitive function in aging individuals and those at risk for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the molecular mechanisms of memory and aging, suggesting that this approach could yield valuable insights.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARNES, CAROL A. — UNIVERSITY OF ARIZONA
- Study coordinator: BARNES, CAROL A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.