Understanding how a specific gene affects memory decline in older adults
Official title: Delineating how epigenetic regulation of ACVR1C contributes to age and AD-related memory impairments in females and males
Funded at Arizona State University-Tempe Campus · NIH-11293766 · Data updated 2026-11-12
This study is looking at how a specific gene might affect memory problems that come with aging and Alzheimer's Disease, and it's for older adults over 65 who want to understand more about what influences their cognitive health and how we might help improve it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | November 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $224,100 |
| NIH project number | 4R00AG078501-03 |
| Project ID | NIH-11293766 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 65 and older who are experiencing cognitive decline or are at risk for Alzheimer's Disease.
✕Less likely to help
Patients under the age of 65 or those without cognitive impairments may not benefit from this research.
What this research studies
This research investigates the role of the ACVR1C gene in memory impairments associated with aging and Alzheimer's Disease (AD). It aims to uncover how epigenetic changes in this gene contribute to cognitive decline in both males and females over the age of 65. By examining the mechanisms behind these changes, the research seeks to identify potential therapeutic targets that could improve cognitive function in older adults. The approach includes experimental studies that assess the gene's impact on memory and synaptic plasticity in animal models.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance memory and cognitive function in older adults at risk for Alzheimer's Disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of genetic factors in cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Keiser, Ashley a — Arizona State University-Tempe Campus
- Study coordinator: Keiser, Ashley a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.