Understanding how a specific gene affects kidney cyst formation
Genetic dissection of ciliary ARL13B in kidney cystogenesis
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-10861794
This study is looking at how a gene called ARL13B affects kidney cysts in people with autosomal dominant polycystic kidney disease (ADPKD), with the hope of finding new ways to treat this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10861794 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the ARL13B gene in the development of kidney cysts associated with autosomal dominant polycystic kidney disease (ADPKD). By focusing on the primary cilium, a cellular structure crucial for signaling, the study aims to identify molecular targets that could lead to new treatments for this condition. The researchers are using advanced techniques to selectively remove ARL13B from cilia, allowing them to better understand its specific functions and the pathways involved in cyst formation. This could provide insights into how to effectively manage or treat ADPKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autosomal dominant polycystic kidney disease (ADPKD).
Not a fit: Patients without a diagnosis of ADPKD or those with other unrelated kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that significantly improve kidney function and quality of life for patients with ADPKD.
How similar studies have performed: Previous research has shown promise in targeting ciliary signaling pathways for therapeutic interventions in kidney diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CASPARY, TAMARA J. — EMORY UNIVERSITY
- Study coordinator: CASPARY, TAMARA J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult Polycystic Kidney Disease, Autosomal Dominant Polycystic Kidney Disease