Understanding how a specific gene affects inflammation during sepsis
Determining the conserved molecular mechanisms contributing to inflammation during Sepsis
This study is looking at how a specific molecule called GAPLINC affects the immune system during sepsis, which is a serious infection, to find new ways to help treat people who are suffering from this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project ID | NIH-10835911 on NIH RePORTER |
What this research studies
This research investigates the role of a long noncoding RNA called GAPLINC in the immune response during sepsis, a severe condition caused by infection. By using genetic mouse models, the researchers will explore how manipulating GAPLINC affects the body's reaction to bacterial infections. They will also study the molecular mechanisms by which GAPLINC influences immune gene expression in both mice and human cells. The goal is to identify new therapeutic targets that could improve treatment options for sepsis patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of or currently experiencing sepsis, particularly those with bacterial infections.
Not a fit: Patients with sepsis caused by non-bacterial infections or those who do not have a significant immune response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve outcomes for patients suffering from sepsis.
How similar studies have performed: Other research has shown promise in targeting molecular mechanisms in sepsis, but the specific approach of targeting GAPLINC is relatively novel.
Where this research is happening
Santa Cruz, United States
- University of California Santa Cruz — Santa Cruz, United States (Active)
Researchers
- Principal investigator: Carpenter, Susan — University of California Santa Cruz
- Study coordinator: Carpenter, Susan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.