Understanding how a specific gene affects immune responses in asthma during viral infections
Official title: Molecular understanding of the GSDMB-regulated innate immune response
Funded at University of Virginia · NIH-11250342 · Data updated 2026-11-12
This study is looking at how a specific gene might affect how children's immune systems respond to respiratory viruses, which can make asthma worse, and it hopes to find ways to help kids with asthma who are more likely to have serious reactions to these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $530,529 |
| NIH project number | 7R01HL162783-03 |
| Project ID | NIH-11250342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have a history of asthma and respiratory viral infections.
✕Less likely to help
Patients who do not have asthma or are older than 11 years may not receive benefit from this research.
What this research studies
This research investigates the role of the Gasdermin B (GSDMB) gene in the immune response to respiratory viruses, particularly focusing on how these infections can trigger asthma exacerbations in children. By examining the innate immune response activated by viral infections, the study aims to uncover the mechanisms that lead to increased susceptibility to asthma in genetically predisposed individuals. The research utilizes advanced molecular techniques to analyze how viral RNA is recognized by the immune system and how this recognition influences the severity of asthma symptoms. The findings could provide insights into personalized treatment strategies for children with asthma who are at risk of severe reactions to respiratory viruses.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for children with asthma, particularly those affected by viral infections.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors influencing asthma exacerbations, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Zhou, Anny Xiaobo — University of Virginia
- Study coordinator: Zhou, Anny Xiaobo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.