Understanding how a specific gene affects gut health in Crohn's disease
Macrophage LRRK2 activity regulates gut epithelial homeostasis
This project explores how a gene called LRRK2, which is linked to Crohn's disease, impacts gut health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11180313 on NIH RePORTER |
What this research studies
We know that Crohn's disease is influenced by both our genes and our environment. This project focuses on a specific gene, LRRK2, which is also connected to Parkinson's disease and can become overactive. We are learning how this overactive LRRK2, particularly in immune cells called macrophages in the gut, might lead to problems with the gut lining, like those seen in Crohn's disease. Our goal is to uncover how these genetic and environmental factors work together to cause gut inflammation.
Who could benefit from this research
Good fit: Patients with Crohn's disease, especially those with specific LRRK2 gene variations, might eventually benefit from this research.
Not a fit: Patients without Crohn's disease or those whose condition is not related to the LRRK2 gene pathway may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new treatment options for Crohn's disease by targeting the LRRK2 gene pathway.
How similar studies have performed: LRRK2-targeted therapies are already being developed for Parkinson's disease, suggesting a promising avenue for similar approaches in Crohn's disease.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Liu, Ta-Chiang — Washington University
- Study coordinator: Liu, Ta-Chiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.