Understanding how a specific gene affects brain cancer growth
Official title: Deciphering the role of pH regulator Slc4a4 in glioma progression
Funded at Baylor College of Medicine · NIH-10984807 · Data updated 2026-11-12
This study is looking at how a specific gene called Slc4a4 affects the growth of brain cancer called malignant glioma, and it hopes to find new ways to treat this condition by understanding how this gene influences the tumor's environment.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $134,582 |
| NIH project number | 1K99CA295327-01A1 |
| Project ID | NIH-10984807 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with malignant glioma who are seeking innovative treatment options.
✕Less likely to help
Patients with non-malignant brain tumors or those without glioma may not benefit from this research.
What this research studies
This research investigates the role of the Slc4a4 gene in the progression of malignant glioma, a type of brain cancer. It aims to understand how this gene regulates pH levels in the tumor microenvironment and how this regulation affects tumor growth and blood vessel formation. By analyzing patient data and conducting experiments in mouse models, the research seeks to uncover the mechanisms by which Slc4a4 influences glioma behavior. Patients may benefit from insights that could lead to new treatment strategies targeting this gene.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that improve outcomes for patients with glioma.
How similar studies have gone: Previous research has shown promising results in targeting metabolic pathways in glioma, suggesting that this approach could be beneficial.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Ye, Qi — Baylor College of Medicine
- Study coordinator: Ye, Qi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.