Understanding how a specific gene affects brain blood vessel function in Alzheimer's disease
Deciphering molecular mechanisms that underlie brain endothelial cell dysfunction with APOE4
This study looks at how a specific gene called APOE4 affects the tiny blood vessels in the brain, which are important for keeping our minds healthy, especially for people at risk of Alzheimer's disease, to help find new ways to support brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11183517 on NIH RePORTER |
What this research studies
This research investigates the role of brain endothelial cells, which are crucial for maintaining the health of the central nervous system, particularly in the context of Alzheimer's disease. It focuses on how the APOE4 gene variant contributes to dysfunction in these cells, potentially leading to cognitive decline and other neurodegenerative issues. By examining the molecular mechanisms involved, the research aims to uncover how APOE4 disrupts the normal functioning of brain blood vessels. This could provide insights into new therapeutic strategies for patients at risk of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with the APOE4 gene variant who are at risk for Alzheimer's disease.
Not a fit: Patients without the APOE4 gene variant or those who do not have any neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve brain blood vessel function and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown that targeting neurovascular dysfunction can lead to improvements in cognitive outcomes, suggesting that this approach may be promising.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Tai, Leon Maing — University of Illinois at Chicago
- Study coordinator: Tai, Leon Maing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.