Understanding how a specific gene affects brain blood vessel function in Alzheimer's disease
Deciphering molecular mechanisms that underlie brain endothelial cell dysfunction with APOE4
This study is looking at how a specific gene called APOE4 affects the tiny blood vessels in the brain, which are important for keeping our brains healthy, especially for people with Alzheimer's disease, to help find better ways to prevent or treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11092272 on NIH RePORTER |
What this research studies
This research investigates the role of brain endothelial cells, which are crucial for maintaining the health of the central nervous system, particularly in the context of Alzheimer's disease. It focuses on how the APOE4 gene variant contributes to dysfunction in these cells, potentially leading to cognitive decline and other neurodegenerative issues. By examining the molecular mechanisms involved, the research aims to uncover how APOE4 disrupts the normal functioning of brain blood vessels. This could lead to new insights into preventing or treating Alzheimer's disease and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to Alzheimer's disease, particularly those carrying the APOE4 variant.
Not a fit: Patients without any genetic risk factors for Alzheimer's disease or those already diagnosed with advanced stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve brain health and cognitive function in individuals at risk for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of APOE in neurodegenerative diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Tai, Leon Maing — University of Illinois at Chicago
- Study coordinator: Tai, Leon Maing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.