Understanding how a specific gene affects aging and genome stability
Molecular mechanisms of Werner syndrome helicase in genome stability and aging
This study is looking into how problems with the WRN gene, which is connected to Werner syndrome, affect aging and cancer risk, and it hopes to find new ways to help people with this condition and improve our understanding of aging in general.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11016936 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms of the WRN gene, which is linked to Werner syndrome, a condition that causes accelerated aging and increased cancer risk. By using advanced techniques like structural biology and single-molecule biochemistry, the research aims to uncover how defects in this gene lead to genomic instability and age-related diseases. Patients with Werner syndrome may benefit from insights gained through this research, which could inform future treatments and interventions. The study also aims to enhance understanding of normal aging processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Werner syndrome or other progeroid syndromes characterized by accelerated aging.
Not a fit: Patients without genetic predispositions to progeroid syndromes or those not experiencing accelerated aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating age-related diseases and improving the quality of life for patients with accelerated aging conditions.
How similar studies have performed: Previous research on progeroid syndromes has shown promise in understanding aging mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Soniat, Michael — Thomas Jefferson University
- Study coordinator: Soniat, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.