Understanding how a specific enzyme is regulated in the body
Allosteric regulation of human cystathionine beta-synthase
This study is looking at how changes in a key enzyme called CBS affect its ability to help keep your body's sulfur levels balanced, which is important for people with conditions like homocystinuria, and it hopes to find ways to improve understanding and treatment for those affected.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10866568 on NIH RePORTER |
What this research studies
This research investigates the regulation of cystathionine beta-synthase (CBS), an enzyme crucial for maintaining healthy levels of sulfur metabolites in the body. By examining how mutations in CBS affect its function, the research aims to uncover the mechanisms behind disorders like homocystinuria, which can impact multiple organ systems. The approach involves detailed biochemical assays to analyze the enzyme's activity under various conditions, particularly focusing on how allosteric regulation influences its performance. Patients may benefit from insights gained about CBS and its role in metabolic pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with homocystinuria or related metabolic disorders caused by CBS mutations.
Not a fit: Patients without any known metabolic disorders or those not affected by CBS dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for conditions related to CBS dysfunction, such as homocystinuria.
How similar studies have performed: Previous research has shown promising results in understanding enzyme regulation and its implications for metabolic disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Roman, Joseph V. — University of Michigan at Ann Arbor
- Study coordinator: Roman, Joseph V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.