Understanding how a specific enzyme influences antibody production
Official title: Orchestration of the antibody response by PI3K-gamma
Funded at Yale University · NIH-11168253 · Data updated 2026-11-12
This study is looking at how a specific enzyme called PI3K-gamma helps our immune system, especially how it affects the way certain immune cells called B cells make antibodies to fight infections, which could lead to better treatments for people with weak immune systems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 6, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $837,497 |
| NIH project number | 1R01AI185063-01A1 |
| Project ID | NIH-11168253 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with inborn errors of immunity or recurrent infections due to antibody deficiencies.
✕Less likely to help
Patients with fully functional immune systems or those not experiencing issues with antibody production may not benefit from this research.
What this research studies
This research investigates the role of the PI3K-gamma enzyme in the immune system, particularly how it affects the production of antibodies by B cells. By studying mouse models, the researchers aim to uncover the molecular mechanisms that enable B cells to differentiate into antibody-secreting cells, which are crucial for fighting infections. The project will explore how signals from PI3K-gamma influence B cell behavior and antibody responses, potentially leading to new therapeutic strategies for patients with immune deficiencies. The findings could provide insights into improving immune responses in individuals with recurrent infections.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with immune deficiencies, enhancing their ability to produce antibodies and fight infections.
How similar studies have gone: Previous research has shown promising results in understanding the role of PI3K in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Lucas, Carrie L. — Yale University
- Study coordinator: Lucas, Carrie L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.