Understanding how a specific enzyme in the intestine affects metabolic health
The role of intestinal SCD1 in regulating metabolic health
This study is looking at how a specific enzyme in the intestines affects fat absorption and overall health, using special mice without this enzyme, to help us understand its role in conditions like heart disease and diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project ID | NIH-11091528 on NIH RePORTER |
What this research studies
This research investigates the role of stearoyl-CoA desaturase-1 (SCD1) in the intestine and its impact on lipid metabolism and overall metabolic health. By using genetically modified mice that lack SCD1 in their intestinal cells, the study aims to uncover how this enzyme influences the absorption and secretion of fats, as well as its effects on energy expenditure and glucose tolerance. The findings could provide insights into how intestinal processes contribute to conditions like cardiovascular disease and insulin resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders such as obesity, insulin resistance, or cardiovascular diseases.
Not a fit: Patients without metabolic disorders or those who do not have issues related to lipid metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing metabolic disorders and improving cardiovascular health.
How similar studies have performed: Previous research has shown promising results in understanding lipid metabolism and its implications for metabolic health, suggesting that this approach could yield valuable insights.
Where this research is happening
Piscataway, United States
- Rutgers, the State Univ of N.j. — Piscataway, United States (Active)
Researchers
- Principal investigator: Sampath, Harini — Rutgers, the State Univ of N.j.
- Study coordinator: Sampath, Harini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.