Understanding how a specific enzyme helps repair damaged metabolites in energy production.
Official title: Unraveling the physiological and metabolic impacts of a universal metabolite repair enzyme that removes a strong inhibitor of the TCA cycle
Funded at University of Minnesota · NIH-11116975 · Data updated 2026-11-12
This study is looking at how a special enzyme helps fix damaged parts of a key energy-making process in our bodies, which could help people with metabolic diseases understand how to stay healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | July 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $368,272 |
| NIH project number | 5R35GM154803-02 |
| Project ID | NIH-11116975 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with metabolic disorders or conditions that affect energy production.
✕Less likely to help
Patients with non-metabolic conditions or those not affected by energy production issues may not receive any benefit from this research.
What this research studies
This research investigates the role of a universal enzyme that repairs damaged metabolites within the TCA cycle, a crucial pathway for energy production in the body. By focusing on how this enzyme functions, the research aims to uncover the physiological and metabolic impacts of metabolite damage and its repair. Patients may benefit from insights into metabolic diseases linked to enzyme dysfunction, as the study explores the mechanisms behind metabolite repair and its importance in maintaining cellular health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating metabolic disorders by enhancing the body's ability to repair damaged metabolites.
How similar studies have gone: Previous research has shown promising results in understanding metabolite repair mechanisms, indicating that this approach has potential for significant advancements in metabolic health.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Niehaus, Thomas D — University of Minnesota
- Study coordinator: Niehaus, Thomas D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.