Understanding how a specific enzyme helps cells manage stress and growth.
Official title: Mechanistic role of phosphatidylinositol 5-phosphate 4-kinase beta in GTP-dependent lysosomal acidification for stress-resilient cell growth and metabolism
Funded at University of Cincinnati · NIH-10986083 · Data updated 2026-11-12
This study is looking at how a specific enzyme helps cells handle stress and grow, which could give us clues about improving health in people with metabolic diseases and cancer, using mice to see what happens when this enzyme is missing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $318,858 |
| NIH project number | 5R01GM144426-03 |
| Project ID | NIH-10986083 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic diseases or cancers that exhibit high anabolic states.
✕Less likely to help
Patients with conditions unrelated to metabolic stress or cancer may not benefit from this research.
What this research studies
This research investigates the role of an enzyme called phosphatidylinositol 5-phosphate 4-kinase beta in helping cells cope with stress while promoting growth and metabolism. By studying how this enzyme influences lysosomal functions, the research aims to uncover mechanisms that could improve our understanding of metabolic diseases and cancers. The approach involves genetic studies in mice to observe how the absence of this enzyme affects cellular responses to stressors like nutrient deprivation and reactive oxygen species. This could lead to insights into how to enhance cell resilience and overall health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating metabolic diseases and cancers by enhancing cellular resilience.
How similar studies have gone: Other research has shown promising results in understanding cellular stress responses, but the specific role of PI5P4Kβ in this context is relatively novel.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Sasaki, Atsuo — University of Cincinnati
- Study coordinator: Sasaki, Atsuo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.