Understanding how a specific enzyme helps build mitochondrial ribosomes
New Mechanisms of the Pseudouridine Synthase Module in Mitoribosome Assembly
['FUNDING_OTHER'] · BAYLOR COLLEGE OF MEDICINE · NIH-10873081
This study is looking at how a specific enzyme helps build the tiny machines in our cells that make proteins, which is especially important for people with mitochondrial diseases, and it hopes to find new ways to help treat these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10873081 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the RPUSD4 pseudouridine synthase in the assembly of mitochondrial ribosomes, which are crucial for protein synthesis in cells. By using advanced techniques from structural biology, genomics, and biochemistry, the research aims to uncover how this enzyme modifies mitochondrial ribosomal RNA and how mutations can disrupt this process. The findings could provide insights into the molecular mechanisms behind mitochondrial diseases, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with mitochondrial disorders, particularly those related to rRNA modifications.
Not a fit: Patients with non-mitochondrial related diseases or conditions unrelated to mitochondrial function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with mitochondrial diseases.
How similar studies have performed: While the specific mechanisms of the RPUSD4 enzyme are underexplored, similar approaches in studying RNA modifications have shown promise in understanding genetic disorders.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PILLON, MONICA — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: PILLON, MONICA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease, Disorder, Genetic Diseases