Understanding how a specific enzyme from Serratia marcescens affects infections
Official title: Defining the role of Serratia marcescens nuclease in infection process
Funded at Marshall University · NIH-10778603 · Data updated 2026-11-12
This study is looking at how a specific enzyme made by a type of bacteria can help it cause infections in people on peritoneal dialysis, with the hope that understanding this could lead to better ways to prevent and treat these infections.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marshall University NIH-funded |
| Lab location | 1 site (Huntington, UNITED STATES) |
| Project start | February 6, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $74,000 |
| NIH project number | 5R03AI175783-02 |
| Project ID | NIH-10778603 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with kidney failure who are undergoing peritoneal dialysis and are at risk of Serratia marcescens infections.
✕Less likely to help
Patients who do not have kidney failure or are not undergoing peritoneal dialysis may not benefit from this research.
What this research studies
This research investigates the role of a particular enzyme produced by the bacteria Serratia marcescens in the process of infection, particularly in patients undergoing peritoneal dialysis. By creating a mouse model, the researchers aim to observe how this enzyme contributes to the bacteria's ability to spread and evade the immune system. The study seeks to fill gaps in knowledge regarding the mechanisms of this opportunistic pathogen, which is known for causing severe infections in hospital settings. The findings could lead to better strategies for managing infections caused by this resistant bacterium.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from infections caused by Serratia marcescens, particularly those on peritoneal dialysis.
How similar studies have gone: While the specific role of this enzyme in Serratia marcescens infections has not been extensively studied, research on similar bacterial pathogens has shown promise in understanding their infection mechanisms.
Where this research is happening
-
Marshall University
Huntington, United States Active
Researchers
- Principal investigator: Bogomolnaya, Lydia M — Marshall University
- Study coordinator: Bogomolnaya, Lydia M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.