Understanding how a specific enzyme affects mutations in breast cancer
Official title: Regulation of APOBEC3 cytidine deaminase-induced mutation during cancerdevelopment
Funded at University of Vermont & St Agric College · NIH-11005220 · Data updated 2026-11-12
This study is looking at how a specific enzyme called APOBEC3A might cause changes in breast cancer cells and how understanding this could help find new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project start | February 6, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $472,605 |
| NIH project number | 5R01CA269784-04 |
| Project ID | NIH-11005220 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with breast cancer, particularly those with mutations linked to the APOBEC signature.
✕Less likely to help
Patients with cancers unrelated to the APOBEC mutation signature may not benefit from this research.
What this research studies
This research investigates the role of the APOBEC3A enzyme in causing mutations in breast cancer cells. It aims to understand how this enzyme is regulated and how its activity contributes to cancer development. The study will explore the mechanisms that lead to increased expression of APOBEC3A in cancer and how this affects DNA repair processes. By identifying the factors that control this enzyme, the research seeks to uncover potential targets for therapeutic intervention.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating breast cancer by targeting the mechanisms of mutation caused by APOBEC3A.
How similar studies have gone: Other research has shown promising results in understanding the role of APOBEC enzymes in cancer, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Vermont & St Agric College
Burlington, United States Active
Researchers
- Principal investigator: Roberts, Steven a — University of Vermont & St Agric College
- Study coordinator: Roberts, Steven a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.