Understanding how a specific enzyme affects melanoma growth and spread
Official title: Investigating the role of GAPDHS in melanoma metabolism and metastasis
Funded at Ut Southwestern Medical Center · NIH-10873245 · Data updated 2026-11-12
This study is looking at how a specific enzyme called GAPDHS affects the growth and spread of melanoma, a serious skin cancer, to see if it can help predict how the cancer will progress in patients and improve treatment options.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $259,752 |
| NIH project number | 5K08CA279757-02 |
| Project ID | NIH-10873245 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are melanoma patients who are undergoing treatment or monitoring for tumor progression.
✕Less likely to help
Patients with non-melanoma skin cancers or those who are not currently diagnosed with melanoma may not benefit from this research.
What this research studies
This research investigates the role of the enzyme GAPDHS in the metabolism and spread of melanoma, a serious form of skin cancer. By studying how GAPDHS influences cancer cell behavior in various environments, the research aims to uncover the metabolic changes that allow melanoma to thrive and spread to other organs. The team will use patient-derived models to explore whether GAPDHS can serve as a biomarker for predicting tumor progression in melanoma patients. The findings could lead to new insights into how to better manage and treat melanoma.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting melanoma progression and potentially new therapeutic targets.
How similar studies have gone: Other research has shown promising results in understanding metabolic pathways in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Gill, Jennifer Gibson — Ut Southwestern Medical Center
- Study coordinator: Gill, Jennifer Gibson
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.