Understanding how a specific enzyme affects learning and memory.
Molecular computation by the CaMKII holoenzyme
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF COLORADO DENVER · NIH-10897283
This study is looking at how a brain enzyme called CaMKII affects learning and memory by helping to strengthen or weaken connections between brain cells, which could lead to better understanding and treatments for memory and learning issues.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10897283 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the CaMKII enzyme in the brain, particularly how it influences learning, cognition, and memory through its interactions with synapses in the hippocampus. The study focuses on the enzyme's ability to mediate two opposing processes—long-term potentiation (LTP) and long-term depression (LTD)—which are essential for synaptic plasticity. By examining the molecular mechanisms and interactions of CaMKII, the research aims to uncover how these processes are regulated and how they contribute to cognitive functions. Patients may benefit from insights gained into the biochemical pathways involved in memory and learning disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive decline or memory disorders, particularly those related to degenerative neurological conditions.
Not a fit: Patients with non-neurological conditions or those not experiencing cognitive issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving cognitive function in individuals with memory-related disorders.
How similar studies have performed: Previous research has shown promising results in understanding synaptic plasticity and its implications for cognitive function, suggesting that this approach has potential for significant advancements.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BROWN, CAROLYN NICOLE — UNIVERSITY OF COLORADO DENVER
- Study coordinator: BROWN, CAROLYN NICOLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.