Understanding how a specific enzyme affects gene regulation during development
The role of DOT1L methyltransferase in controlling the noncoding transcriptome
['FUNDING_R01'] · BOSTON UNIVERSITY MEDICAL CAMPUS · NIH-10669669
This study is looking at how a specific protein called DOT1L helps control gene activity during the development of animals, which could help us understand important processes in humans, especially in relation to cancers like leukemia and breast cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY MEDICAL CAMPUS (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10669669 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the DOT1L methyltransferase in regulating gene expression during animal development, particularly focusing on its connection to RNA interference and the production of double-stranded RNA. By studying the interactions between DOT1L and other proteins, the research aims to uncover how these mechanisms influence the expression of non-coding RNAs, which are crucial for proper cellular function. The research employs molecular and genomic techniques to analyze these relationships in model organisms like C. elegans, with implications for understanding similar processes in humans, especially in relation to conditions like leukemia and breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by congenital defects or cancers, particularly those with a family history of these conditions.
Not a fit: Patients with unrelated health conditions or those not affected by congenital abnormalities or cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatment strategies for cancers and congenital abnormalities.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation through similar mechanisms, indicating potential for success in this area.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY MEDICAL CAMPUS — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRISHOK, ALLA — BOSTON UNIVERSITY MEDICAL CAMPUS
- Study coordinator: GRISHOK, ALLA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Cancers