Understanding how a specific enzyme affects fatty liver disease
Investigating the role of Lipocalin Prostaglandin D2 Synthase and its metabolite PGD2 in non-alcoholic fatty liver disease
['FUNDING_OTHER'] · ST. JOHN'S UNIVERSITY · NIH-10936921
This study is looking at how a specific protein and its byproduct might affect the development of non-alcoholic fatty liver disease (NAFLD), especially in people who are dealing with insulin resistance and obesity, to help find better ways to treat the condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JOHN'S UNIVERSITY (nih funded) |
| Locations | 1 site (QUEENS, UNITED STATES) |
| Trial ID | NIH-10936921 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Lipocalin Prostaglandin D2 Synthase (L-PGDS) and its metabolite PGD2 in the development of non-alcoholic fatty liver disease (NAFLD). The study aims to uncover the molecular mechanisms behind NAFLD, particularly focusing on how insulin signaling influences L-PGDS expression and function. By using animal models, the researchers will explore the relationship between L-PGDS, insulin resistance, and obesity, which are critical factors in the progression of NAFLD. The findings could lead to a better understanding of the disease and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-alcoholic fatty liver disease, particularly those with insulin resistance or obesity.
Not a fit: Patients with alcoholic liver disease or those without any liver-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for non-alcoholic fatty liver disease, improving patient outcomes.
How similar studies have performed: While there have been studies on NAFLD, the specific investigation of L-PGDS and its role in the disease is relatively novel and has not been extensively tested.
Where this research is happening
QUEENS, UNITED STATES
- ST. JOHN'S UNIVERSITY — QUEENS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KUMAR, SUNIL — ST. JOHN'S UNIVERSITY
- Study coordinator: KUMAR, SUNIL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.