Understanding how a specific enzyme affects fatty liver disease
Official title: Investigating the role of Lipocalin Prostaglandin D2 Synthase and its metabolite PGD2 in non-alcoholic fatty liver disease
Funded at St. John's University · NIH-10936921 · Data updated 2026-11-12
This study is looking at how a specific protein and its byproduct might affect the development of non-alcoholic fatty liver disease (NAFLD), especially in people who are dealing with insulin resistance and obesity, to help find better ways to treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. John's University NIH-funded |
| Lab location | 1 site (Queens, United States) |
| Project start | August 10, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $187,500 |
| NIH project number | 1R16GM150498-01A1 |
| Project ID | NIH-10936921 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with non-alcoholic fatty liver disease, particularly those with insulin resistance or obesity.
✕Less likely to help
Patients with alcoholic liver disease or those without any liver-related conditions may not benefit from this research.
What this research studies
This research investigates the role of Lipocalin Prostaglandin D2 Synthase (L-PGDS) and its metabolite PGD2 in the development of non-alcoholic fatty liver disease (NAFLD). The study aims to uncover the molecular mechanisms behind NAFLD, particularly focusing on how insulin signaling influences L-PGDS expression and function. By using animal models, the researchers will explore the relationship between L-PGDS, insulin resistance, and obesity, which are critical factors in the progression of NAFLD. The findings could lead to a better understanding of the disease and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for non-alcoholic fatty liver disease, improving patient outcomes.
How similar studies have gone: While there have been studies on NAFLD, the specific investigation of L-PGDS and its role in the disease is relatively novel and has not been extensively tested.
Where this research is happening
-
St. John's University
Queens, United States Active
Researchers
- Principal investigator: Kumar, Sunil — St. John's University
- Study coordinator: Kumar, Sunil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.