Understanding how a specific enzyme affects breast cancer growth and spread
Defining the Critical Function and Regulation of NNMT in Breast Cancer Progression and Metastasis
This study is looking at how a specific protein called NNMT affects the growth and spread of a type of breast cancer known as basal-like breast cancer, with the hope of finding new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11059896 on NIH RePORTER |
What this research studies
This research investigates the role of N-methyltransferase (NNMT) in breast cancer, particularly in a subtype known as basal-like breast cancer (BLBC). The study aims to understand how NNMT contributes to cancer cell growth and metastasis, especially when cells detach from their surrounding tissue. By using advanced techniques like CRISPR-Cas9, researchers will explore how NNMT is regulated and its potential as a target for new treatments. The findings could lead to improved strategies for managing breast cancer progression and treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with basal-like breast cancer who may benefit from targeted therapies.
Not a fit: Patients with other subtypes of breast cancer or those not diagnosed with breast cancer may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets and strategies for treating breast cancer more effectively.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Zhou, Binhua P — University of Kentucky
- Study coordinator: Zhou, Binhua P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.