Understanding how a specific enzyme affects brain development and function
Molecular functions of the TRMT1 tRNA modification enzyme
['FUNDING_R01'] · UNIVERSITY OF ROCHESTER · NIH-10813155
This study is looking at how a special enzyme called TRMT1 affects brain growth and thinking skills by examining mice without this enzyme, which could help us understand more about certain intellectual disabilities related to changes in TRMT1.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10813155 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the TRMT1 enzyme, which modifies tRNA, in brain development and function. By studying mice that lack this enzyme, researchers aim to uncover how TRMT1 influences cognitive abilities and growth. The project employs advanced techniques like tRNA sequencing and ribosome profiling to analyze the stability and function of tRNAs in relation to neurodevelopment. The findings could provide insights into the biological mechanisms behind intellectual disabilities linked to TRMT1 mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with intellectual disabilities linked to genetic mutations affecting tRNA modification.
Not a fit: Patients without genetic mutations related to tRNA modification or those with different types of intellectual disabilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for intellectual disabilities caused by TRMT1 mutations.
How similar studies have performed: While the specific focus on TRMT1 is novel, previous studies have shown success in understanding the role of tRNA modifications in other contexts.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FU, DRAGONY — UNIVERSITY OF ROCHESTER
- Study coordinator: FU, DRAGONY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.