Understanding how a specific enhancer affects immune response proteins
Role of the DR/DQ super enhancer in MHC-II expression
This study is looking at how a special part of our DNA helps control important proteins that help our immune system recognize and fight off infections, which could lead to better understanding and treatments for autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10877985 on NIH RePORTER |
What this research studies
This research investigates the role of a super enhancer in regulating the expression of major histocompatibility complex class-II (MHC-II) proteins, which are crucial for the immune system's ability to present antigens to T cells. By utilizing advanced techniques such as 3C-based methods and ATAC sequencing, the study aims to uncover the complex interactions within the chromatin architecture that influence MHC-II gene expression. Patients may benefit from insights gained about how immune responses are initiated and sustained, particularly in the context of autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with autoimmune diseases or those interested in understanding their immune system better.
Not a fit: Patients with conditions unrelated to immune response or those not affected by autoimmune diseases may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses in patients with autoimmune diseases.
How similar studies have performed: Previous research has shown success in understanding gene regulation through chromatin architecture, suggesting that this approach may yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Boss, Jeremy M. — Emory University
- Study coordinator: Boss, Jeremy M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.