Understanding how a specific Ebola virus variant increases infectivity
Insight into the Ebola virus glycoprotein fusion mechanism gleaned from the 2013-2016 epidemic GP-A82V variant
['FUNDING_R01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-10747371
This study is looking into a specific version of the Ebola virus that was common during the 2013-2016 outbreak to see how it helps the virus infect human cells better, using advanced tools and tests to learn more about its structure and behavior.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-10747371 on ClinicalTrials.gov |
What this research studies
This research investigates the GP-A82V variant of the Ebola virus, which became prevalent during the 2013-2016 outbreak. The team aims to understand how this variant enhances the virus's ability to infect human cells. They will use advanced techniques such as computer modeling, molecular dynamics simulations, and various assays to explore the glycoprotein's structure and function. Additionally, the research will assess the variant's impact on virus replication in human cells and humanized mouse models.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit would include individuals at risk of Ebola virus exposure or those involved in outbreak response efforts.
Not a fit: Patients who are not at risk of Ebola virus exposure or who have no history of Ebola infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures against Ebola virus infections.
How similar studies have performed: Other research has shown success in understanding viral mechanisms through similar approaches, but this specific variant's investigation is relatively novel.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUBAN, JEREMY — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: LUBAN, JEREMY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.