Understanding how a specific DNA modification affects gene regulation in human cells
Official title: Control mechanisms of 5-hydroxymethylcytosine metabolism in human cells
Funded at Texas A&m University-Kingsville · NIH-10917033 · Data updated 2026-11-12
This study is looking at a special part of our DNA that might help protect against cancer, and it's for anyone interested in how changes in our genes could lead to new treatments for cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University-Kingsville NIH-funded |
| Lab location | 1 site (Kingsville, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $138,000 |
| NIH project number | 5R16GM145578-02 |
| Project ID | NIH-10917033 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with glioblastomas or lymphomas, particularly those who have shown resistance to current therapies.
✕Less likely to help
Patients with cancers unrelated to 5hmC alterations or those not diagnosed with glioblastomas or lymphomas may not benefit from this research.
What this research studies
This research investigates the role of 5-hydroxymethylcytosine (5hmC) in human DNA, particularly its impact on gene expression and its association with various cancers. The project aims to identify the proteins that control the formation of 5hmC in human neurons, using advanced techniques like CRISPR/Cas9 to manipulate DNA. By studying these mechanisms, the research hopes to uncover how 5hmC contributes to cancer resistance and survival rates. Patients may benefit from insights gained that could lead to new therapeutic strategies targeting these epigenetic changes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers associated with 5hmC loss, improving patient outcomes.
How similar studies have gone: While the specific approach of targeting 5hmC in this manner is relatively novel, there is growing evidence supporting the significance of epigenetic modifications in cancer treatment.
Where this research is happening
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Texas A&m University-Kingsville
Kingsville, United States Active
Researchers
- Principal investigator: Kim, Haeyoung — Texas A&m University-Kingsville
- Study coordinator: Kim, Haeyoung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.