Understanding how a specific choline transporter affects myelin formation in brain cells.
Unveiling CTL1 as the Key Choline Transporter in Oligodendrocytes: Implication for Myelin Formation and Maintenance
['FUNDING_R21'] · RUTGERS THE STATE UNIV OF NJ NEWARK · NIH-11038943
This study is looking at how a specific protein helps brain cells called oligodendrocytes get the nutrients they need to repair myelin, which is important for brain health, and it could lead to new treatments for conditions like multiple sclerosis.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS THE STATE UNIV OF NJ NEWARK (nih funded) |
| Locations | 1 site (NEWARK, UNITED STATES) |
| Trial ID | NIH-11038943 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the choline transporter-like 1 (CTL1) in oligodendrocytes, which are cells responsible for forming myelin in the brain. By exploring how these cells acquire choline, an essential nutrient for myelin production, the study aims to uncover mechanisms that could enhance myelin repair, particularly in conditions like multiple sclerosis. The research will involve examining the expression of CTL1 during myelination and its implications for brain health. Patients may benefit from insights that could lead to new treatments for myelin-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with conditions affecting myelin, particularly those with multiple sclerosis or related disorders.
Not a fit: Patients with conditions unrelated to myelin formation or maintenance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for conditions that involve myelin damage, such as multiple sclerosis.
How similar studies have performed: Previous studies have shown promise in understanding choline's role in myelination, suggesting that this research could build on established findings.
Where this research is happening
NEWARK, UNITED STATES
- RUTGERS THE STATE UNIV OF NJ NEWARK — NEWARK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIM, HAESUN A — RUTGERS THE STATE UNIV OF NJ NEWARK
- Study coordinator: KIM, HAESUN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.