Understanding how a specific choline transporter affects myelin formation in brain cells.
Official title: Unveiling CTL1 as the Key Choline Transporter in Oligodendrocytes: Implication for Myelin Formation and Maintenance
Funded at Rutgers the State Univ of Nj Newark · NIH-11038943 · Data updated 2026-11-12
This study is looking at how a specific protein helps brain cells called oligodendrocytes get the nutrients they need to repair myelin, which is important for brain health, and it could lead to new treatments for conditions like multiple sclerosis.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers the State Univ of Nj Newark NIH-funded |
| Lab location | 1 site (Newark, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $235,500 |
| NIH project number | 1R21NS140995-01 |
| Project ID | NIH-11038943 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with conditions affecting myelin, particularly those with multiple sclerosis or related disorders.
✕Less likely to help
Patients with conditions unrelated to myelin formation or maintenance may not benefit from this research.
What this research studies
This research investigates the role of the choline transporter-like 1 (CTL1) in oligodendrocytes, which are cells responsible for forming myelin in the brain. By exploring how these cells acquire choline, an essential nutrient for myelin production, the study aims to uncover mechanisms that could enhance myelin repair, particularly in conditions like multiple sclerosis. The research will involve examining the expression of CTL1 during myelination and its implications for brain health. Patients may benefit from insights that could lead to new treatments for myelin-related disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for conditions that involve myelin damage, such as multiple sclerosis.
How similar studies have gone: Previous studies have shown promise in understanding choline's role in myelination, suggesting that this research could build on established findings.
Where this research is happening
-
Rutgers the State Univ of Nj Newark
Newark, United States Active
Researchers
- Principal investigator: Kim, Haesun a — Rutgers the State Univ of Nj Newark
- Study coordinator: Kim, Haesun a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.