Understanding how a specific cell death pathway affects inflammation and immunity
Official title: Transcriptional Outputs of the Necroptotic Pathway
Funded at University of Washington · NIH-11125032 · Data updated 2026-11-12
This study is looking at a special kind of cell death called necroptosis to see how it affects the immune system and inflammation, which could help us understand diseases like cancer and autoimmune disorders better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 9, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $350,000 |
| NIH project number | 1R56AI179665-01A1 |
| Project ID | NIH-11125032 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune diseases or cancers where necroptosis may play a significant role.
✕Less likely to help
Patients with conditions unrelated to necroptosis or those not experiencing inflammation or immune dysregulation may not benefit from this research.
What this research studies
This research investigates necroptosis, a type of cell death that plays a role in immune responses and diseases like cancer and autoimmunity. The study aims to uncover how the necroptotic pathway influences immune signaling and inflammation, focusing on specific proteins involved in this process. Researchers will conduct experiments in cultured cells and in live mice to observe the effects of necroptosis on immune responses and cytokine production. By understanding these mechanisms, the research hopes to clarify the relationship between cell death and inflammation.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing autoimmune diseases and cancer by targeting the necroptotic pathway.
How similar studies have gone: Previous research has shown promising results in understanding necroptosis and its implications in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Oberst, Andrew Atwell — University of Washington
- Study coordinator: Oberst, Andrew Atwell
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.