Understanding how a specific cardiac receptor complex functions in heart failure
Regulation of a cardiac b1AR/SERCA2 complex in heart failure
This study is looking at how certain receptors in heart cells work and how they can be affected by an enzyme, with the goal of finding new ways to help improve heart function for people with heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10870097 on NIH RePORTER |
What this research studies
This research investigates the role of a cardiac receptor complex in heart failure, focusing on how the b1-adrenergic receptors (b1ARs) behave inside heart cells. It aims to uncover the internal signaling mechanisms of these receptors, particularly at the sarcoplasmic reticulum, which may be crucial for heart function. The study will explore how the enzyme monoamine oxidase A (MAOA) affects the availability of catecholamines, which are important for heart contractility, especially during stress. By understanding these processes, the research seeks to identify new therapeutic targets for improving heart function in patients with heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure who may benefit from improved cardiac function.
Not a fit: Patients without heart failure or those with other unrelated cardiac conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and quality of life for patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding adrenergic signaling in heart failure, but this specific approach focusing on internal receptor mechanisms is relatively novel.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Xiang, Yang K — University of California at Davis
- Study coordinator: Xiang, Yang K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.