Understanding how a specific cancer mutation affects colorectal cancer progression
A cancer-derived truncating mutation in disease penetrance and progression of MSI CRC
This study is looking at how a specific change in the UVRAG gene affects the growth of certain types of colorectal cancer, and it aims to find out how this change might help doctors better understand and treat patients with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wistar Institute NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10745933 on NIH RePORTER |
What this research studies
This research investigates the role of a truncating mutation in the UVRAG gene and its impact on the progression of microsatellite instability (MSI) colorectal cancer (CRC). The study aims to uncover the molecular mechanisms by which this mutation contributes to tumor development and disease severity. By collaborating with experts in genetics, molecular biology, and clinical practice, the research seeks to identify how centrosome amplification interacts with DNA mismatch repair deficiencies in CRC. Patients may benefit from insights that could lead to improved diagnostic and therapeutic strategies for MSI CRC.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Lynch Syndrome or sporadic early colorectal cancer exhibiting microsatellite instability.
Not a fit: Patients with colorectal cancer not associated with microsatellite instability or those without genetic predispositions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with microsatellite instability colorectal cancer.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors influencing colorectal cancer, making this approach a continuation of established findings.
Where this research is happening
Philadelphia, United States
- Wistar Institute — Philadelphia, United States (Active)
Researchers
- Principal investigator: Liang, Chengyu — Wistar Institute
- Study coordinator: Liang, Chengyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.