Understanding how a specific calcium channel in mitochondria works
Molecular Physiology of Mitochondrial Calcium Uniporter
This study is looking at how a special protein helps move calcium into the energy factories of our cells, which is important for keeping our cells healthy, and it could help us understand and find new treatments for diseases like heart problems and brain disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11077215 on NIH RePORTER |
What this research studies
This research investigates the mitochondrial calcium uniporter complex, which is crucial for transporting calcium into mitochondria, affecting energy production and cell survival. By using advanced techniques like gene knockout and patch-clamp methodology, the study aims to explore how different components of this complex interact and regulate calcium entry. The findings could provide insights into various diseases linked to mitochondrial dysfunction, such as heart failure and neurodegeneration, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions such as heart failure, neurodegenerative diseases, or certain types of cancer.
Not a fit: Patients with conditions unrelated to mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to mitochondrial dysfunction, enhancing patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function and its implications in various diseases, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Garg, Vivek — University of Maryland Baltimore
- Study coordinator: Garg, Vivek
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.