Understanding how a specific calcium channel in mitochondria works
Official title: Molecular Physiology of Mitochondrial Calcium Uniporter
Funded at University of Maryland Baltimore · NIH-11077215 · Data updated 2026-11-12
This study is looking at how a special protein helps move calcium into the energy factories of our cells, which is important for keeping our cells healthy, and it could help us understand and find new treatments for diseases like heart problems and brain disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | June 15, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $339,900 |
| NIH project number | 5R01GM145806-03 |
| Project ID | NIH-11077215 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions such as heart failure, neurodegenerative diseases, or certain types of cancer.
✕Less likely to help
Patients with conditions unrelated to mitochondrial dysfunction may not benefit from this research.
What this research studies
This research investigates the mitochondrial calcium uniporter complex, which is crucial for transporting calcium into mitochondria, affecting energy production and cell survival. By using advanced techniques like gene knockout and patch-clamp methodology, the study aims to explore how different components of this complex interact and regulate calcium entry. The findings could provide insights into various diseases linked to mitochondrial dysfunction, such as heart failure and neurodegeneration, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to mitochondrial dysfunction, enhancing patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial function and its implications in various diseases, indicating that this approach has potential for success.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Garg, Vivek — University of Maryland Baltimore
- Study coordinator: Garg, Vivek
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.