Understanding how a specific brain region helps retrieve memories.
Official title: The Neglected Subiculum: Decoding and Manipulating Memory Retrieval with Multiphoton Holography
Funded at Columbia University Health Sciences · NIH-10861912 · Data updated 2026-11-12
This study is looking at how a specific part of the brain called the subiculum helps us remember things, especially in people with Alzheimer's disease, and it hopes to find new ways to improve memory by understanding how this area works.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $49,974 |
| NIH project number | 5F99NS134209-02 |
| Project ID | NIH-10861912 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing memory impairments, particularly those diagnosed with Alzheimer's disease.
✕Less likely to help
Patients with memory impairments not related to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of the subiculum, a part of the brain, in memory retrieval, particularly in the context of Alzheimer's disease. Using advanced techniques like two-photon calcium imaging and holographic photostimulation, the study aims to decode and manipulate the activity of neurons in the subiculum during memory retrieval in mice. By exploring how this brain region contributes to recalling memories, the research seeks to fill a critical gap in our understanding of memory impairment associated with Alzheimer's. The findings could lead to new insights into memory function and potential therapeutic targets for memory-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing memory retrieval in patients with Alzheimer's disease.
How similar studies have gone: While the specific focus on the subiculum in memory retrieval is less explored, similar approaches in other brain regions have shown promising results in understanding memory processes.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: O'neil, Darik Andrew — Columbia University Health Sciences
- Study coordinator: O'neil, Darik Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.