Understanding how a specific brain region affects memory in aging and Alzheimer's disease
Dissecting the role of the dentate gyrus microcircuit to improve cognitive discrimination in aging and Alzheimer's Disease
This study is looking at how a specific part of the brain helps us remember and tell apart similar experiences, especially as we age or if we have Alzheimer's, and it aims to see if boosting the growth of new brain cells can help improve memory for older adults and those facing memory challenges.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10592865 on NIH RePORTER |
What this research studies
This research investigates the role of the dentate gyrus, a part of the brain involved in memory processing, particularly in how it helps distinguish between similar experiences. It focuses on how aging and Alzheimer's disease impact this function, which is crucial for cognitive discrimination. The study will utilize advanced genetic techniques and neural recordings to explore how increasing the production of new neurons in this region can improve memory performance in older adults and those with cognitive impairments.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who are experiencing normal aging, Mild Cognitive Impairment, or Alzheimer's disease.
Not a fit: Patients with other forms of dementia or cognitive impairments unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance memory and cognitive function in aging individuals and those affected by Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in enhancing cognitive functions through neurogenesis, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Losonczy, Attila — Columbia University Health Sciences
- Study coordinator: Losonczy, Attila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.