Understanding how a specific brain region affects eating behavior in older adults

Role of the parasubthalamic nucleus (PSTN) in the central regulation of feeding behavior

NIH-funded research Williams College · NIH-11043682

This study is looking at how a specific part of the brain called the parasubthalamic nucleus affects hunger and eating habits in older adults, to help understand how it can influence issues like not eating enough or overeating.

Quick facts

Grant typeR15 grant
Study typeNIH-funded research
Funding institutionWilliams College NIH-funded
Lab location1 site (Williamstown, United States)
Project IDNIH-11043682 on NIH RePORTER

What this research studies

This research investigates the role of the parasubthalamic nucleus (PSTN) in regulating appetite and feeding behavior, particularly in older adults. By examining the neural connections and activity patterns of this brain region, the study aims to uncover how it influences hunger and appetite suppression. The research will involve analyzing how different stimuli affect the PSTN and its impact on eating behaviors, which can be crucial for addressing issues like undernourishment and obesity in the elderly.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals aged 65 and older who may experience appetite-related issues.

Not a fit: Patients under the age of 65 or those without appetite regulation problems may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to new treatments for appetite regulation, helping older adults maintain a healthy weight and improve their nutritional status.

How similar studies have performed: While the role of the PSTN in appetite regulation is relatively understudied, similar research on other brain regions has shown promising results in understanding feeding behavior.

Where this research is happening

Williamstown, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.