Understanding how a specific brain protein affects social behavior in children with autism.
Discovery of a cerebellar-specific BAF chromatin remodeler that is necessary for social inhibition: molecular and circuit mechanisms
This study is looking at how a protein called ACTL6B might be linked to social behavior challenges in children with autism, using both family data and animal models to help find ways to better understand and treat autism.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10893948 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called ACTL6B in autism spectrum disorder (ASD) by studying both human families with mutations in this gene and animal models. The researchers aim to uncover the molecular mechanisms that lead to social behavior challenges in children with ASD. By analyzing brain activity and genetic factors, they hope to identify how changes in this protein affect brain function and behavior. This work could lead to better understanding and potential treatments for ASD.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with autism spectrum disorder, particularly those with mutations in the ACTL6B gene.
Not a fit: Patients who do not have autism spectrum disorder or those without mutations in the ACTL6B gene may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into the biological basis of autism, potentially leading to improved therapies and interventions for affected children.
How similar studies have performed: Other research has shown success in identifying genetic factors related to autism, making this approach promising yet still exploring novel aspects of the condition.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Wenderski, Wendy — Stanford University
- Study coordinator: Wenderski, Wendy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.