Understanding how a specific brain pathway affects walking after a stroke.
Official title: Elucidating the role of the contralesional corticoreticulospinal tract for lower limb function after stroke.
Funded at University of Illinois at Chicago · NIH-10782552 · Data updated 2026-11-12
This study is looking at how a specific brain pathway can help people who have had a stroke improve their walking abilities, with the hope of finding better ways to support their recovery and independence.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $199,875 |
| NIH project number | 5R21NS126808-02 |
| Project ID | NIH-10782552 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a stroke and are facing challenges with walking and lower limb function.
✕Less likely to help
Patients who have not had a stroke or those with severe cognitive impairments may not benefit from this research.
What this research studies
This research investigates the role of the corticoreticulospinal tract, a brain pathway, in improving lower limb function for individuals who have experienced a stroke. The study aims to identify how this pathway from the non-affected side of the brain can be enhanced to support recovery of walking abilities. By using advanced measurement tools, researchers will assess the functionality of this pathway and its influence on motor control of the affected limb. The ultimate goal is to improve rehabilitation strategies for stroke survivors, helping them regain independence in mobility.
Why it matters
Potential benefit: If successful, this research could lead to more effective rehabilitation techniques that enhance walking recovery for stroke patients.
How similar studies have gone: Previous research has shown promise in enhancing motor pathways for stroke recovery, indicating that this approach could yield significant insights.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Madhavan, Sangeetha — University of Illinois at Chicago
- Study coordinator: Madhavan, Sangeetha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.