Understanding how a specific brain channel contributes to nerve cell death.
Investigations into ASIC1a-dependent neuronal death
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11094101
This study is looking at how a specific channel in nerve cells might cause damage during brain injuries when blood flow is low, and it aims to find ways to protect the brain from this harm, which could help improve treatments for people with brain injuries.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11094101 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the acid-sensing ion channel 1a (ASIC1a) in causing nerve cell death during brain injuries, particularly when the brain experiences reduced blood flow. The researchers aim to understand how modifying this channel or activating certain receptors can prevent this toxic effect without disrupting its normal functions. By exploring these mechanisms, the study seeks to identify new ways to protect the brain from damage during ischemic events, which could lead to innovative treatments for brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced brain injuries or conditions that lead to ischemia.
Not a fit: Patients with non-ischemic brain conditions or those who do not have any history of brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect nerve cells from damage during brain injuries.
How similar studies have performed: Previous research has shown promise in targeting similar ion channels for neuroprotection, suggesting that this approach may yield beneficial results.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ASKWITH, CANDICE C — OHIO STATE UNIVERSITY
- Study coordinator: ASKWITH, CANDICE C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury