Understanding how a specific brain area affects sleep problems caused by opioids
Unraveling the Locus Coeruleus Circuitry in Opioidinduced Sleep Disturbances
This study is looking at how a specific part of the brain affects sleep problems caused by opioid use, and it's aimed at helping people who struggle with sleep issues related to their opioid medications.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10893584 on NIH RePORTER |
What this research studies
This research investigates the role of the locus coeruleus, a brain region, in sleep disturbances that occur due to opioid use. The principal investigator, Dr. Li, will study how neuronal activity in this area relates to sleep patterns in mice that have been given opioids. By examining the effects of local opioid receptors in the locus coeruleus, the research aims to uncover mechanisms that contribute to sleep issues associated with opioid use. This could lead to better understanding and potential treatments for patients experiencing these disturbances.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are using opioids and experiencing sleep disturbances.
Not a fit: Patients who are not using opioids or do not have sleep disturbances related to opioid use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management of sleep disturbances in patients using opioids, enhancing their overall quality of life.
How similar studies have performed: While the specific focus on the locus coeruleus in relation to opioid-induced sleep disturbances is relatively novel, there have been successful studies examining sleep disturbances in other contexts.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Li, Li — Seattle Children's Hospital
- Study coordinator: Li, Li
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.