Understanding how a specific bacterium affects tooth decay in young children
Probing the role of Selenomonas sputigena in supragingival biofilm spatial structuring and virulence
This study is looking at how a specific bacteria called Selenomonas sputigena helps create harmful plaque on teeth, especially in young kids with Early Childhood Caries, to find ways to prevent and treat tooth decay better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11014412 on NIH RePORTER |
What this research studies
This research investigates the role of the bacterium Selenomonas sputigena in the formation of harmful biofilms on teeth, particularly in young children suffering from Early Childhood Caries (ECC). By examining how this bacterium interacts with other bacteria and its motility on tooth surfaces, the research aims to uncover mechanisms that contribute to tooth decay. The study employs advanced techniques in microbiology and biophysics to analyze biofilm dynamics and spatial structuring. The findings could lead to better prevention and treatment strategies for ECC.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-5 years who are at risk for or currently experiencing Early Childhood Caries.
Not a fit: Patients who are older than 11 years or do not have any dental caries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for preventing and treating tooth decay in young children.
How similar studies have performed: Previous research has shown promising results in understanding the role of specific bacteria in dental health, indicating that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Ren, Zhi — University of Pennsylvania
- Study coordinator: Ren, Zhi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.