Understanding how a specific bacterial secretion system affects infections and cancer development
Official title: Type VII secretion in Streptococcus gallolyticus pathogenesis
Funded at Texas A&m University Health Science Ctr · NIH-11144671 · Data updated 2026-11-12
This study is looking at how a specific system in the Streptococcus gallolyticus bacteria might help it cause serious infections and possibly lead to colon cancer, with the goal of understanding how it affects the gut and contributes to disease, which could help improve health outcomes for people at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | December 1, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $78,152 |
| NIH project number | 3R01AI163206-02S1 |
| Project ID | NIH-11144671 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of colorectal cancer or those at high risk for infections related to Streptococcus gallolyticus.
✕Less likely to help
Patients without any history of colorectal cancer or related infections may not benefit from this research.
What this research studies
This research investigates the role of the type VII secretion system in the pathogenicity of Streptococcus gallolyticus, a bacterium linked to severe bloodstream infections and colorectal cancer. The study aims to uncover how this bacterium interacts with the intestinal lining and contributes to disease progression. By using pre-clinical models, researchers will explore the mechanisms by which Sgg promotes colon cancer cell growth and translocates across epithelial barriers. The findings could provide insights into the virulence factors of Sgg and their impact on human health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating infections and colorectal cancer associated with Streptococcus gallolyticus.
How similar studies have gone: Other research has shown promising results in understanding bacterial virulence mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Xu, Yi — Texas A&m University Health Science Ctr
- Study coordinator: Xu, Yi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.