Understanding how a specific bacteria causes severe diarrhea
Official title: Molecular Pathogenesis of enterotoxigenic E. coli associated enteropathy
Funded at Washington University · NIH-11001543 · Data updated 2026-11-12
This study is looking at how a type of bacteria called ETEC causes serious diarrhea and affects the health of children, especially in low-income areas, to find ways to help them grow better and stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | January 15, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $532,892 |
| NIH project number | 5R01AI170949-03 |
| Project ID | NIH-11001543 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adults who have experienced severe diarrhea or malnutrition linked to ETEC infections.
✕Less likely to help
Patients who do not have a history of ETEC infection or related gastrointestinal conditions may not benefit from this research.
What this research studies
This research investigates enterotoxigenic Escherichia coli (ETEC), a major cause of serious diarrhea, particularly in children from low-income regions. The study aims to uncover the molecular mechanisms by which ETEC leads to environmental enteropathy, a condition that results in malnutrition and stunted growth. By analyzing the bacteria's impact on the small intestine, the research seeks to identify potential interventions that could improve health outcomes for affected individuals. The findings may also shed light on related conditions such as tropical sprue.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for diarrheal diseases caused by ETEC, ultimately saving lives and enhancing the quality of life for affected populations.
How similar studies have gone: Previous research has shown success in understanding the pathogenesis of similar bacterial infections, indicating that this approach has the potential for meaningful advancements.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Fleckenstein, James Michael — Washington University
- Study coordinator: Fleckenstein, James Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.