Understanding how a specific bacteria causes severe diarrhea
Molecular Pathogenesis of enterotoxigenic E. coli associated enteropathy
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-11001543
This study is looking at how a type of bacteria called ETEC causes serious diarrhea and affects the health of children, especially in low-income areas, to find ways to help them grow better and stay healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11001543 on ClinicalTrials.gov |
What this research studies
This research investigates enterotoxigenic Escherichia coli (ETEC), a major cause of serious diarrhea, particularly in children from low-income regions. The study aims to uncover the molecular mechanisms by which ETEC leads to environmental enteropathy, a condition that results in malnutrition and stunted growth. By analyzing the bacteria's impact on the small intestine, the research seeks to identify potential interventions that could improve health outcomes for affected individuals. The findings may also shed light on related conditions such as tropical sprue.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adults who have experienced severe diarrhea or malnutrition linked to ETEC infections.
Not a fit: Patients who do not have a history of ETEC infection or related gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for diarrheal diseases caused by ETEC, ultimately saving lives and enhancing the quality of life for affected populations.
How similar studies have performed: Previous research has shown success in understanding the pathogenesis of similar bacterial infections, indicating that this approach has the potential for meaningful advancements.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FLECKENSTEIN, JAMES MICHAEL — WASHINGTON UNIVERSITY
- Study coordinator: FLECKENSTEIN, JAMES MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.