Understanding how a specific bacteria causes gum disease
A novel mechanism of virulence control in Porphyromonas gingivalis
This study is looking at how certain bacteria that cause gum disease behave and change, which could help us understand why gum disease gets worse and lead to better treatments for people dealing with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10876470 on NIH RePORTER |
What this research studies
This research investigates the role of CRISPR-Cas systems in the bacteria Porphyromonas gingivalis, which is known to cause severe gum disease in adults. By analyzing how these systems affect the bacteria's ability to cause disease, the research aims to uncover microbial signals that correlate with the progression of periodontal disease. The study will involve comparing gene activity in normal and mutated bacteria to better understand their virulence. This could lead to new insights into how gum disease develops and progresses in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing symptoms of severe periodontal disease.
Not a fit: Patients with mild gum disease or those who do not have periodontal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for periodontal disease, potentially reducing its severity and associated health complications.
How similar studies have performed: Previous research has shown success in understanding bacterial mechanisms in other diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Frias-Lopez, Jorge — University of Florida
- Study coordinator: Frias-Lopez, Jorge
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.