Understanding how a specific bacteria affects gum disease
Regulatory Mechanisms Controlling P. gingivalis Surface Structures
['FUNDING_R01'] · ADA FORSYTH INSTITUTE, INC. · NIH-11082997
This study is looking at how a bacteria called Porphyromonas gingivalis, which is known to cause gum disease, creates its protective outer layer and how it becomes more harmful, with the goal of understanding how it affects your oral health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ADA FORSYTH INSTITUTE, INC. (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11082997 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which Porphyromonas gingivalis, a bacteria linked to periodontal disease, produces its protective capsule and membrane lipids. By studying the genetic and biochemical pathways involved, the research aims to uncover how this bacteria transitions to a more virulent state, potentially leading to gum disease and related health issues. The approach includes manipulating specific RNA molecules and proteins that regulate these processes, providing insights into bacterial behavior and its impact on human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are at risk for or currently experiencing periodontal disease.
Not a fit: Patients who do not have periodontal disease or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating periodontal disease and its associated health complications.
How similar studies have performed: Previous research has shown that understanding bacterial mechanisms can lead to significant advancements in treating related diseases, suggesting a promising avenue for this investigation.
Where this research is happening
CAMBRIDGE, UNITED STATES
- ADA FORSYTH INSTITUTE, INC. — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAVEY, MARY ELLEN — ADA FORSYTH INSTITUTE, INC.
- Study coordinator: DAVEY, MARY ELLEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.