Understanding how a specific bacteria affects gum disease
Official title: Regulatory Mechanisms Controlling P. gingivalis Surface Structures
Funded at Ada Forsyth Institute, INC. · NIH-11082997 · Data updated 2026-11-12
This study is looking at how a bacteria called Porphyromonas gingivalis, which is known to cause gum disease, creates its protective outer layer and how it becomes more harmful, with the goal of understanding how it affects your oral health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ada Forsyth Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | May 2, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $598,960 |
| NIH project number | 5R01DE033659-02 |
| Project ID | NIH-11082997 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are at risk for or currently experiencing periodontal disease.
✕Less likely to help
Patients who do not have periodontal disease or are under 21 years old may not benefit from this research.
What this research studies
This research investigates the mechanisms by which Porphyromonas gingivalis, a bacteria linked to periodontal disease, produces its protective capsule and membrane lipids. By studying the genetic and biochemical pathways involved, the research aims to uncover how this bacteria transitions to a more virulent state, potentially leading to gum disease and related health issues. The approach includes manipulating specific RNA molecules and proteins that regulate these processes, providing insights into bacterial behavior and its impact on human health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating periodontal disease and its associated health complications.
How similar studies have gone: Previous research has shown that understanding bacterial mechanisms can lead to significant advancements in treating related diseases, suggesting a promising avenue for this investigation.
Where this research is happening
-
Ada Forsyth Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Davey, Mary Ellen — Ada Forsyth Institute, INC.
- Study coordinator: Davey, Mary Ellen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.