Understanding how a specific bacteria affects Group B Streptococcus in pregnant women
Official title: Elucidating the role of Akkermansia muciniphila in Group B Streptococcal vaginal colonization and ascending infection
Funded at University of Colorado Denver · NIH-10994911 · Data updated 2026-11-12
This study is looking at how two types of bacteria, Group B Streptococcus and Akkermansia muciniphila, interact in the female genital area during pregnancy, to better understand how they might affect the health of mothers and their babies.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | November 1, 2024 |
| Project end | October 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 1F32AI186285-01 |
| Project ID | NIH-10994911 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women who are carriers of Group B Streptococcus.
✕Less likely to help
Patients who are not pregnant or do not carry Group B Streptococcus may not benefit from this research.
What this research studies
This research investigates the relationship between Group B Streptococcus (GBS) and the bacteria Akkermansia muciniphila in the female genital tract, particularly during pregnancy. It aims to uncover how these bacteria interact and influence GBS colonization, which can lead to serious pregnancy complications such as preterm birth and infections in newborns. Using a mouse model, the study will explore the mechanisms behind this interaction and its implications for maternal and neonatal health.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing GBS-related complications in pregnant women and their infants.
How similar studies have gone: Previous studies have shown that understanding the microbiome's role in bacterial colonization can lead to significant advancements in maternal and neonatal health, suggesting potential success for this research.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Marroquin, Stephanie Michelle — University of Colorado Denver
- Study coordinator: Marroquin, Stephanie Michelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.